Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study
Identifieur interne : 001A96 ( Main/Exploration ); précédent : 001A95; suivant : 001A97Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study
Auteurs : Jaffar A. Al-Tawfiq [Arabie saoudite, États-Unis] ; Hisham Momattin [Arabie saoudite] ; Jean Dib [Arabie saoudite] ; Ziad A. Memish [Arabie saoudite]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Coronavirus (), Diabète (virologie), Femelle, Humains, Hypertension artérielle (), Imipénem (usage thérapeutique), Infections de l'appareil respiratoire (traitement médicamenteux), Infections de l'appareil respiratoire (virologie), Infections à coronavirus (), Infections à coronavirus (traitement médicamenteux), Insuffisance rénale chronique (), Interféron alpha (usage thérapeutique), Jeune adulte, Maladie grave (), Mâle, Protéines recombinantes (usage thérapeutique), Ribavirine (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Ventilation artificielle, Études rétrospectives.
- MESH :
- traitement médicamenteux : Infections de l'appareil respiratoire, Infections à coronavirus.
- usage thérapeutique : Antiviraux, Imipénem, Interféron alpha, Protéines recombinantes, Ribavirine.
- virologie : Diabète, Infections de l'appareil respiratoire.
- Adulte, Adulte d'âge moyen, Coronavirus, Femelle, Humains, Hypertension artérielle, Infections à coronavirus, Insuffisance rénale chronique, Jeune adulte, Maladie grave, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Ventilation artificielle, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antiviral Agents (therapeutic use), Coronavirus (drug effects), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Critical Illness (therapy), Diabetes Mellitus (virology), Female, Humans, Hypertension (complications), Imipenem (therapeutic use), Interferon alpha-2, Interferon-alpha (therapeutic use), Male, Middle Aged, Recombinant Proteins (therapeutic use), Renal Insufficiency, Chronic (complications), Respiration, Artificial, Respiratory Tract Infections (drug therapy), Respiratory Tract Infections (virology), Retrospective Studies, Ribavirin (therapeutic use), Treatment Outcome, Young Adult.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Imipenem, Interferon-alpha, Recombinant Proteins, Ribavirin.
- complications : Coronavirus Infections, Hypertension, Renal Insufficiency, Chronic.
- drug effects : Coronavirus.
- drug therapy : Coronavirus Infections, Respiratory Tract Infections.
- therapy : Critical Illness.
- virology : Diabetes Mellitus, Respiratory Tract Infections.
- Adult, Aged, Aged, 80 and over, Female, Humans, Interferon alpha-2, Male, Middle Aged, Respiration, Artificial, Retrospective Studies, Treatment Outcome, Young Adult.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) has been reported to have a high case-fatality rate. Currently, there is no specific therapy or vaccine with proven effectiveness for MERS-CoV infections.
A combination of ribavirin and interferon therapy was used for the treatment of five MERS-CoV-positive patients. We reviewed the therapeutic schedule and the outcome of these patients.
All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. The median time from admission to therapy with ribavirin and interferon was 19 (range 10–22) days. None of the patients responded to the supportive or therapeutic interventions and all died of their illness.
While ribavirin and interferon may be effective in some patients, our practical experience suggests that critically ill patients with multiple comorbidities who are diagnosed late in the course of their illness may not benefit from combination antiviral therapy as preclinical data suggest. There is clearly an urgent need for a novel effective antiviral therapy for this emerging global threat.
Url:
DOI: 10.1016/j.ijid.2013.12.003
PubMed: 24406736
PubMed Central: 7110882
Affiliations:
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Le document en format XML
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Al-Tawfiq</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Internal Medicine, Saudi Aramco Medical Services Organization, PO Box 76, Room A-428-2, Building 61, Dhahran Health Center, Dhahran 31311, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Internal Medicine, Saudi Aramco Medical Services Organization, PO Box 76, Room A-428-2, Building 61, Dhahran Health Center, Dhahran 31311</wicri:regionArea><wicri:noRegion>Dhahran 31311</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Indiana University School of Medicine, Indiana, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Indiana University School of Medicine, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Momattin, Hisham" sort="Momattin, Hisham" uniqKey="Momattin H" first="Hisham" last="Momattin">Hisham Momattin</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Pharmacy Services Division, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Pharmacy Services Division, Saudi Aramco Medical Services Organization, Dhahran</wicri:regionArea><wicri:noRegion>Dhahran</wicri:noRegion></affiliation></author><author><name sortKey="Dib, Jean" sort="Dib, Jean" uniqKey="Dib J" first="Jean" last="Dib">Jean Dib</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Pharmacy Services Division, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Pharmacy Services Division, Saudi Aramco Medical Services Organization, Dhahran</wicri:regionArea><wicri:noRegion>Dhahran</wicri:noRegion></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation wicri:level="1"><nlm:aff id="aff0020">WHO Collaborating Center for Mass Gathering Medicine, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>WHO Collaborating Center for Mass Gathering Medicine, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Al-Faisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Al-Faisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus (drug effects)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (drug therapy)</term><term>Critical Illness (therapy)</term><term>Diabetes Mellitus (virology)</term><term>Female</term><term>Humans</term><term>Hypertension (complications)</term><term>Imipenem (therapeutic use)</term><term>Interferon alpha-2</term><term>Interferon-alpha (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Recombinant Proteins (therapeutic use)</term><term>Renal Insufficiency, Chronic (complications)</term><term>Respiration, Artificial</term><term>Respiratory Tract Infections (drug therapy)</term><term>Respiratory Tract Infections (virology)</term><term>Retrospective Studies</term><term>Ribavirin (therapeutic use)</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antiviraux (usage thérapeutique)</term><term>Coronavirus ()</term><term>Diabète (virologie)</term><term>Femelle</term><term>Humains</term><term>Hypertension artérielle ()</term><term>Imipénem (usage thérapeutique)</term><term>Infections de l'appareil respiratoire (traitement médicamenteux)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Insuffisance rénale chronique ()</term><term>Interféron alpha (usage thérapeutique)</term><term>Jeune adulte</term><term>Maladie grave ()</term><term>Mâle</term><term>Protéines recombinantes (usage thérapeutique)</term><term>Ribavirine (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Ventilation artificielle</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Imipenem</term><term>Interferon-alpha</term><term>Recombinant Proteins</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Hypertension</term><term>Renal Insufficiency, Chronic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Critical Illness</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Imipénem</term><term>Interféron alpha</term><term>Protéines recombinantes</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Diabète</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Diabetes Mellitus</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Interferon alpha-2</term><term>Male</term><term>Middle Aged</term><term>Respiration, Artificial</term><term>Retrospective Studies</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus</term><term>Femelle</term><term>Humains</term><term>Hypertension artérielle</term><term>Infections à coronavirus</term><term>Insuffisance rénale chronique</term><term>Jeune adulte</term><term>Maladie grave</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Ventilation artificielle</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) has been reported to have a high case-fatality rate. Currently, there is no specific therapy or vaccine with proven effectiveness for MERS-CoV infections.</p></sec><sec><title>Methods</title><p>A combination of ribavirin and interferon therapy was used for the treatment of five MERS-CoV-positive patients. We reviewed the therapeutic schedule and the outcome of these patients.</p></sec><sec><title>Results</title><p>All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. The median time from admission to therapy with ribavirin and interferon was 19 (range 10–22) days. None of the patients responded to the supportive or therapeutic interventions and all died of their illness.</p></sec><sec><title>Conclusions</title><p>While ribavirin and interferon may be effective in some patients, our practical experience suggests that critically ill patients with multiple comorbidities who are diagnosed late in the course of their illness may not benefit from combination antiviral therapy as preclinical data suggest. There is clearly an urgent need for a novel effective antiviral therapy for this emerging global threat.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Penttinen, P M" uniqKey="Penttinen P">P.M. Penttinen</name></author><author><name sortKey="Kaasik Aaslav, K" uniqKey="Kaasik Aaslav K">K. Kaasik-Aaslav</name></author><author><name sortKey="Friaux, A" uniqKey="Friaux A">A. Friaux</name></author><author><name sortKey="Donachie, A" uniqKey="Donachie A">A. 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Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C. Martellaro</name></author><author><name sortKey="Callison, J" uniqKey="Callison J">J. Callison</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H. Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author><author><name sortKey="Rasmussen, A L" uniqKey="Rasmussen A">A.L. Rasmussen</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F. Feldmann</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A. Okumura</name></author><author><name sortKey="Scott, D P" uniqKey="Scott D">D.P. Scott</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></noRegion><name sortKey="Dib, Jean" sort="Dib, Jean" uniqKey="Dib J" first="Jean" last="Dib">Jean Dib</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Momattin, Hisham" sort="Momattin, Hisham" uniqKey="Momattin H" first="Hisham" last="Momattin">Hisham Momattin</name></country><country name="États-Unis"><region name="Indiana"><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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